ENTEROBACTER-AEROGENES PNEUMONIA TREATED WITH CEFEPIME-SULBACTAM-GENTAMICIN COMBINATION

BACKGROUND: Enterobocter aerogenes is the fifth most frequent pathogen causing nosocomial infections. Several strains have developed multipl e resistance by over-production of a natural cephalosporinase and by t he presence of wide-spectrum betalactamases. CASE REPORT: A patient wi th chronic respiratory failure developed Enterobacter aerogenes pneumo nia while under mechanical ventilation. The infection was successfully treated with a cefepime, sulbactam, gentamycin combination. DISCUSSIO N: Choosing the optimum antibiotic therapy is a difficult task in many nosocomial infections. In certain cases, combining a beta-lactamase i nhibitor with the appropriate antibiotic can improve bactericidal acti vity and provide successful cure.