ADAPTIVE REACTIONS OF THE CARDIORESPIRATO RY SYSTEM IN CHRONIC-BRONCHITIS AND ITS PREMORBID FORMS

Aim. Investigation of pulmonary ventilation, bloodflow and cardiodynam ics in subjects at risk of chronic nonspecific pulmonary disease (CNPD ), prebronchitis (PB) and chronic bronchitis (CB). Materials and Metho ds. 118 workers exposed to toxico-chemical factors underwent zonal rhe ography. Results. At early stages of CB marked disorders of pulmonary ventilation and bloodflow in the lungs were revealed. These disorders in subjects with threatened CNPD were regional and accompanied by a mo derate increase in power imputs of the cardiorespiratory system. The m aintenance of adequate pulmonary exchange in patients with PB entailed functional tension of the respiratory and cardiovascular systems that contributed to decompensation of adaptive mechanisms and occasionally to development of rheographic signs of pneumosclerosis in the lung zo nes with damaged ventilation and low perfusion of the pulmonary vessel s. Conclusion. Overloading and decompensation of respiratory and cardi al mechanisms of gas exchange regulation in the lungs in response to e xternal damage may lead to development of myocardiodystrophy and pneum osclerosis which appear to be the ''price of adaptation.''.