CLINICOIMMUNOLOGICAL EFFICACY OF CHRONIC- BRONCHITIS TREATMENT WITH LIKOPID

Aim. Elucidation of likopid effect on clinical and immunological pictu res in patients with chronic bronchitis (CB). Materials and Methods. A trial of 52 CB patients in remission and exacerbation. 2 schemes of l ikopid treatment were used: 1 mg/day for 10 days (a course close 10 mg ); 10 mg/day for 6 days (a course dose 60 mg). Clinical and laboratory parameters, systemic immunity (measurement of lymphocyte subpopulatio ns, levels of serum IgA, IgM and IgG, functional activity of periphera l blood phagocytes). Results: The 10 mg and 60 mg courses of likopid p roduced prolongation of remission to 5-6 months in 66% of CB patients in exacerbation and in 80% of patients in remission, respectively. 10 mg of likopid in exacerbation and 60 mg in remission promoted normaliz ation of functional activity of blood phagocytes. Conclusion. Likopid administration for CB in a 10 mg course close in exacerbation and 60 m g course in remission prolongs CB remission to 5-6 months and promoted normalization of phagocytic functional activity.