BLOOD SYSTEM MALIGNANCIES - AGE, CHOLESTE ROL LEVEL AND RED-CELL COUNT

Aim. Illustration of potentialities of computer technologies in proces sing data from case histories. Materials and Methods. Routine clinical and laboratory data on 263 hemoblastosis patients were processed with the use of the exploring system. Results. A paradoxycal negative rela tionship was discovered between blood cholesterol and age (R = -0.345, p < 0.00001), and a positive correlation between cholesterol and numb er of red cells (R = 0.379, p < 0.00001). In comparison of groups with low and high cholesterol, the latter group showed more favourable val ues of hemoglobin, red cells, other hematological and biochemical para meters. It seems that among hemoblastosis patients and healthy subject s there are subjects with standard age-related changes of cholesterol and paradoxycal changes (a negative correlation). The conception about high level of cholesterol as a factor stimulating proliferation of no rmal and affected cells in patients with hemoblastoses appears doubtfu l. At least if is not correct to connect a combination hypocholesterol emia+anemia with low pool of dividing cells. On the contrary, hypochol esterolemia in hemoblastoses indicates active tumor process with conse quent anemia. Conclusion. Investigation of paradoxycal relationships b etween age, cholesterol and red cell count (hemoglobin) will help unde rstand general mechanisms of regulation of hemo- and immunogenesis in blood malignancies.