CUMULATIVE CONCEPTION AND LIVE BIRTH-RATES AFTER OOCYTE DONATION - IMPLICATIONS REGARDING ENDOMETRIAL RECEPTIVITY

The purpose of the present study was to determine the cumulative likel ihood of pregnancy success after repetitive cycles of oocyte donation and specifically to examine the influence of recipient age and diagnos is upon the cumulative Likelihood of pregnancy in an effort to identif y any potential subgroup of recipients who might have diminished endom etrial receptivity, We retrospectively analysed the outcome of 418 con secutive embryo transfer cycles among 276 recipients of oocyte donatio n in our institution. We analysed clinical pregnancy and delivery rate s in the recipients divided by age groups and diagnostic groups, For t he purpose of life-table analysis, only cycles prior to and including the first cycle producing a successful pregnancy were included, Frozen -thawed embryo transfers were not included in the analysis. The overal l clinical pregnancy rate was 36.2% (95% CI 31-41%) and the cumulative pregnancy rate after four cycles was 87.9%. The overall delivery rate was 29.3% (95% CI 25-33%) and the cumulative delivery rate after four cycles was 86.1%. There were no statistically significant differences in any of the rates attributable to recipient age or diagnosis. No de cline in per cycle success was noted over consecutive cycles. We concl ude that neither recipient age nor diagnosis plays a substantial role in the success of oocyte donation, implying that endometrial receptivi ty is unaltered by age or diagnosis. Furthermore, up to four successiv e cycles of oocyte donation are associated with the same probability o f success.