Fp. Chen, MOLAR PREGNANCY AND LIVING NORMAL FETUS COEXISTING UNTIL TERM - PRENATAL BIOCHEMICAL AND SONOGRAPHIC DIAGNOSIS, Human reproduction, 12(4), 1997, pp. 853-856
The extremely rare condition of molar pregnancy with a coexisting fetu
s progressing to a viable infant, is reported, At 20 weeks gestational
age, prenatal diagnosis was made by biochemical and sonographic findi
ngs, in which elevated free beta-human chorionic gonadotrophin (HCG, 5
00 ng/ml) was noted and ultrasound showed a well-defined multicystic s
nowstorm-like mass connecting with placenta, Chromosomal evaluation by
amniocentesis was normal (46,XY) and ultrasound showed no fetal abnor
malities, so the patient decided to keep the pregnancy and had no sign
ificant complications noted in the antepartal period, At 38 weeks gest
ational age, a Caesarean section was performed due to cephalopelvic di
sproportion and a 3380 g, living boy was delivered. The infant did not
show any abnormality. The placenta and the connecting hydatidiform mo
lar tissue were delivered manually, Subsequently, since persistent ele
vated beta-HCG was noted 2 months later, the patient was treated with
chemotherapy for gestational trophoblastic disease, A normal beta-HCG
concentration was noted thereafter, Prenatal differential diagnosis an
d postnatal management are discussed as well as the rationale for allo
wing the pregnancy to continue after the diagnosis at 20 weeks gestati
onal age.