EFFECTS OF SYSTEMATIC TREATMENT BASED ON OVERNIGHT SIMULTANEOUS MONITORING OF ELECTROENCEPHALOGRAPHY AND CYSTOMETRY

Objective: To clarify the effects of systematic treatment based on ove rnight simultaneous monitoring by electroencephalography (EEG) and cys tometry (CM) on each type of enuresis. Methods: For anuresis type I, t he change in the awakening response during the conditioning treatment with a therapeutic machine was observed. For enuresis type IIa, the ef fect of imipramine on the EEG was observed. For enuresis type IIb, the effect of oxybutynin hydrochloride on the cystometrogram (CMG) was ob served. Results: Values, in which the awakening score on the second ni ght was subtracted from the score on the last night, were significantl y higher in the effective cases than in the unchanged cases. Out of th e 3 patients in whom imipramine was effective, an awakening response o n the EEG was observed in 2. Neither of the 2 unchanged cases showed a n awakening response. Out of 4 patients in whom oxybutynin hydrochlori de was effective, uninhibited contractions (UIC) on the CMG disappeare d in 3. UIC stopped in neither of the 2 unchanged cases. Conclusions: Improvement of the awakening response plays an important role in the e ffectiveness of conditioning treatment with our therapeutic machine. T he generation of awakening response is thought to be the most importan t result of imipramine directly concerned with its clinical effect on enuresis type IIa. The main result with oxybutynin hydrochloride in en uresis type IIb is thought to be related to its antispasmodic effect.