Background A growing body of evidence suggests that electromagnetic in
terference may occur between cardiac pacemakers and wireless hand-held
(cellular) telephones, posing a potential public health problem. Elec
tromagnetic interference may occur when the pacemaker is exposed to an
electromagnetic field generated by the cellular telephone. Methods In
this multicenter, prospective, cross-over study, we tested 980 patien
ts with cardiac pacemakers with five types of telephones (one analogue
and four digital) to assess the potential for interference. Telephone
s were tested in a test mode and were programmed to transmit at the ma
ximal power, simulating the worst-case scenario; in addition, one tele
phone was tested during actual transmission to simulate actual use. Pa
tients were electrocardiographically monitored while the telephones we
re tested at the ipsilateral ear and in a series of maneuvers directly
over the pacemaker. Interference was classified according to the type
and clinical significance of the effect. Results The incidence of any
type of interference was 20 percent in the 5533 tests, and the incide
nce of symptoms was 7.2 percent. The incidence of clinically significa
nt interference was 6.6 percent. There was no clinically significant i
nterference when the telephone was placed in the normal position over
the ear. Interference that was definitely clinically significant occur
red in only 1.7 percent of tests, and only when the telephone was held
over the pacemaker. Interference was more frequent with dual-chamber
pacemakers (25.3 percent) than with single-chamber pacemakers (6.8 per
cent, P < 0.001) and more frequent with pacemakers without feed-throug
h filters (28.9 to 55.8 percent) than with those with such filters (0.
4 to 0.8 percent, P = 0.01). Conclusions Cellular telephones can inter
fere with the function of implanted cardiac pacemakers. However, when
telephones are placed over the ear, the normal position, this interfer
ence does not pose a health risk. (C) 1997, Massachusetts Medical Soci
ety.