TRIMERIC G-ALPHA-BETA-GAMMA PROTEIN COUPLING TO A 3D MODEL OF G-PROTEIN-COUPLED RECEPTORS CONFIRMING A NEW MOLECULAR MECHANISM FOR ACTIVATION

Authors
NEDERKOORN PHJ DAVIES RH TIMMS D TIMMERMAN H
Citation
Phj. Nederkoorn et al., TRIMERIC G-ALPHA-BETA-GAMMA PROTEIN COUPLING TO A 3D MODEL OF G-PROTEIN-COUPLED RECEPTORS CONFIRMING A NEW MOLECULAR MECHANISM FOR ACTIVATION, Receptors & channels, 5(2), 1997, pp. 91
Citations number
32
Journal title
Receptors & channels → ACNP
ISSN journal
10606823
Volume
5
Issue
2
Year of publication
1997
Database
ISI
SICI code
1060-6823(1997)5:2<91:TGPCTA>2.0.ZU;2-B
Abstract
The present-day model for G protein activation and the associated theo ry on how a G protein-coupled receptor may activate the G protein are summarized. Experimental data are outlined which seem not to be in acc ordance with this present-day model. An alternative molecular mechanis m for ternary complex activation is presented together with a three-di mensional model for a receptor coupled to the appropriate trimeric G p rotein. This 3D structure confirms our new molecular mechanism of acti vation.