This paper outlines some of the central features of the approach to hi
storical epistemology developed by Georges Canguilhem and argues for t
heir contemporary significance in relation to recent changes in the li
fe sciences. It develops this in relation to three lines of enquiry. T
he first concerns the specific characteristics of scientific reason. T
he second concerns the relations between knowledge of life and life it
self. The third concerns the role that historical work on scientific r
eason can play within contemporary critical thought. In each area it p
roposes some developments of Canguilhem's approach, and illustrates th
is with examples from biology, medicine and psychology.