KRIMPSIEKTE IN A SHEEP FOLLOWING A SINGLE-DOSE OF TYLECODON-VENTRICOSUS (BURM. F) TOELKEN AND THE ISOLATION OF TYLEDOSIDE-D FROM THIS PLANT-SPECIES

Tylecodon ventricosus induced severe respiratory distress in two penne d sheep without any electrocardiographic abnormalities being recorded. Based on the results it appears as if T. ventricosus predominantly in duces the neuromuscular syndrome referred to as krimpsiekte. A single, relatively large intraruminal dose of 10,0 g/kg induced krimpsiekte i n one sheep. Treatment with 5,0 g/kg activated charcoal on two consecu tive days did not prevent the development of krimpsiekte. A bufadienol ide, tyledoside D, was isolated from semi-dried plant material.