GENOMIC STRUCTURE OF THE HUMAN DNA METHYLTRANSFERASE GENE

We determined the genomic structure of the gene encoding human DNA met hyltransferase (DNA MTase). Six overlapping human genomic DNA clones w hich include all of the known cDNA sequence were isolated. Analysis of these clones demonstrates that the human DNA MTase gene consists of a t least 40 exons and 39 introns spanning a distance of 60 kilobases. E lucidation of the chromosomal organization of the human DNA MTase gene provides the template for future structure-function analysis of the p roperties of mammalian DNA MTase.