N. Pisanti et al., LACK OF EFFECT OF GEMFIBROZIL ON CYCLOSPORINE BLOOD-CONCENTRATIONS INKIDNEY-TRANSPLANTED PATIENTS, American journal of nephrology, 18(3), 1998, pp. 199-203
Forty kidney-transplanted patients with hypertriglyceridemia, under tr
eatment with cyclosporine alone or associated with other immunosuppres
sive drugs, were treated with gemfibrozil. This drug, for a long-term
treatment (ranging from 4 to 6 months), was able to decrease hypertrig
lyceridemia and did not modify either polyclonal (P) and monoclonal (M
) cyclosporine blood levels or P/M ratio. These data seem to exclude a
n effect of gemfibrozil on cyclosporine blood concentrations. Therefor
e, the use of gemfibrozil in kidney-transplanted patients does not req
uire modifications of cyclosporine dose.