POTENTIALIZATION OF IL-2 EFFECTS ON IMMUNE CELLS BY OYSTER EXTRACT (JCOE) IN NORMAL AND HIV-INFECTED INDIVIDUALS

Authors
ACHOUR A LACHGAR A ASTGEN A CHAMS V BIZZINI B TAPIERO H ZAGURY D
Citation
A. Achour et al., POTENTIALIZATION OF IL-2 EFFECTS ON IMMUNE CELLS BY OYSTER EXTRACT (JCOE) IN NORMAL AND HIV-INFECTED INDIVIDUALS, Biomedicine & pharmacotherapy, 51(10), 1997, pp. 427-429
Citations number
6
Categorie Soggetti
Pharmacology & Pharmacy","Medicine, Research & Experimental
Journal title
Biomedicine & pharmacotherapy → ACNP
ISSN journal
07533322
Volume
51
Issue
10
Year of publication
1997
Pages
427 - 429
Database
ISI
SICI code
0753-3322(1997)51:10<427:POIEOI>2.0.ZU;2-7
Abstract
Peripheral blood mononuclear cells (PBMCs) are physiologically activat ed by interleukin (IL)-2. We found that oyster extract (JCOE) currentl y used as a functional nutrient enhanced in vitro the IL-2 dependent a ctivation as measured by cell count, H-3-thymidine uptake and up-regul ation of a IL-2 receptor. In human immunodeficiency virus (HIV) seropo sitive individuals, this oyster extract-induced effect was marked in a symptomatic individuals with quasi-normal CD4 cell counts, but was wea kly reflected in acquired immunodeficiency syndrome (AIDS) patients.