C. Chany, INVOLVEMENT OF TEMPERATURE-SENSITIVE SYNCYTIUM INDUCING VSV OR DEFECTIVE RETROVIRUSES IN THE DEVELOPMENT OF SPONGIFORM ENCEPHALOPATHIES, Biomedicine & pharmacotherapy, 51(10), 1997, pp. 446-448
Citations number
10
Categorie Soggetti
Pharmacology & Pharmacy","Medicine, Research & Experimental
Various enveloped viruses can induce syncytia in competent cells. Some
temperature-sensitive mutants can express the trans-membrane viral G
antigen under non-permissive conditions. The G antigen can then migrat
e at long distances, engulfing thousands of cells without producing an
y virus. When a temperature-sensitive vesicular stomatitis virus (VSV)
infects a sensitive host, and under the condition that the G antigen
is expressed, spongiosis can be induced in the central nervous system
in the absence of detectable virus multiplication. We postulate that s
uch a mechanism might be observed with various enveloped viruses, as r
ecently illustrated with knock-out mice experimentally infected with d
efective murine leukemia virus (MULV).