PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE-NERVE TERMINALS DENSELY INNERVATE CORTICOTROPIN-RELEASING HORMONE-NEURONS IN THE HYPOTHALAMIC PARAVENTRICULAR NUCLEUS OF THE RAT

Authors
LEGRADI G HANNIBAL J LECHAN RM
Citation
G. Legradi et al., PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE-NERVE TERMINALS DENSELY INNERVATE CORTICOTROPIN-RELEASING HORMONE-NEURONS IN THE HYPOTHALAMIC PARAVENTRICULAR NUCLEUS OF THE RAT, Neuroscience letters, 246(3), 1998, pp. 145-148
Citations number
23
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
246
Issue
3
Year of publication
1998
Pages
145 - 148
Database
ISI
SICI code
0304-3940(1998)246:3<145:PACPTD>2.0.ZU;2-O
Abstract
Pituitary adenylate cyclase-activating polypeptide (PACAP) is widely d istributed in many regions of the hypothalamus including the paraventr icular nucleus (PVN). In this study, using well-characterized antibodi es against PACAP and corticotropin-releasing hormone (CRH), we identif ied numerous nerve fibers with PACAP-immunoreactivity (ir) closely app osed to CRH neurons in the medial parvocellular subdivision of the rat PVN. Electron microscopy revealed the presence of synapses between PA CAP-ir containing terminals and CRH-perikarya and -dendrites. These mo rphological observations suggest that PACAP may modulate the activatio n of the hypothalamic-pituitary-adrenal axis. (C) 1998 Elsevier Scienc e Ireland Ltd.