PERSISTENT QEEG ABNORMALITY IN CRACK COCAINE USERS AT 6 MONTHS OF DRUG ABSTINENCE

Citation
Kr. Alper et al., PERSISTENT QEEG ABNORMALITY IN CRACK COCAINE USERS AT 6 MONTHS OF DRUG ABSTINENCE, Neuropsychopharmacology, 19(1), 1998, pp. 1-9
Citations number
65
Categorie Soggetti
Neurosciences,Psychiatry,"Pharmacology & Pharmacy
Journal title
Neuropsychopharmacology
ISSN journal
0893133X → ACNP
Volume
19
Issue
1
Year of publication
1998
Pages
1 - 9
Database
ISI
SICI code
0893-133X(1998)19:1<1:PQAICC>2.0.ZU;2-I
Abstract
The major objective of this study was to examine the persistence of ab normal quantitative EEG (qEEG) measures over a six month time interval in subjects in strictly supervised drug free residential treatment fo r crack cocaine dependence. Seventeen subjects were assessed with qEEG at five to 10 days, one month and six months following their last use of cocaine. No significant changes were noted over time in abnormal q EEG measures, which included deficits of absolute and relative power i n the delta band and increased relative alpha power. The persistence o f qEEG abnormality in crack cocaine withdrawal suggests a persistent n eurobiologic alteration resulting from chronic cocaine exposure. The s pecificity of the qEEG findings is discussed, and an interpretation is suggested with reference to the hypothesis of neural sensitization in cocaine dependence. (C) 1998 American College of Neuropsychopharmacol ogy. Published by Elsevier Science Inc.