Migraine is a chronic, sometimes debilitating, condition that tends to
afflict young people who are otherwise healthy and productive, Becaus
e diagnostic criteria and effective treatment modalities have not been
well taught to physicians, the condition is often undiagnosed, misdia
gnosed, and mismanaged, causing unnecessary pain, hardship to the indi
vidual, disability, loss of productivity, and increased expense to the
healthcare system. This paper discusses a rational approach to the be
havioral and pharmacologic treatment of migraine, highlighting the rel
ative costs of preventive and acute care therapies. Several cases are
presented to illustrate how the costs of inefficiently managed migrain
e therapy can be decreased even by using medications that have a highe
r per-dose cost, as they decrease the pain and disability and actually
lower the total cost of managing the patient with migraine.