IN-VITRO BACTERICIDAL ACTIVITIES AND MORPHOLOGIC CHANGES IN ESCHERICHIA-COLI AND BACTEROIDES-FRAGILIS BY CEPHALOSPORINS

Polymicrobial infections with aerobes and anaerobes are common in pelv ic inflammatory diseases. New parenteral cephalosporins have been wide ly used against those infections. We investigated in vitro morphologic changes and bactericidal activities on Escherichia coli and Bacteroid es fragilis by cephalosporins; cefluprenam (CFLP), ceftazidime (CAZ) o r cefotaxime (CTX), CFLP induced morphologic changes (filamentation) a nd bactericidal activities on E. coli and B. fragilis. Morphologic cha nges were observed by electron microscope. The filamentation induced b y CFLP was time and concentration dependent. The bactericidal activity of CFLP against E. coli was almost equal to those of CAZ and CTX. The bactericidal activity of CTX against B. fragilis was superior to thos e of CFLP and CAZ, These results suggest that there are characteristic aspects in each cephalosporin.