PREMATURE EJACULATION AND SEROTONERGIC ANTIDEPRESSANTS-INDUCED DELAYED EJACULATION - THE INVOLVEMENT OF THE SEROTONERGIC SYSTEM

Premature ejaculation has generally been considered a psychosexual dis order with psychogenic aetiology. Although still mainly treated by beh avioural therapy, in recent years double-blind studies have indicated the beneficial effects of some of the serotonergic antidepressants (SS RIs) in delaying ejaculation We describe here the neurophysiology and the peripheral neuroanatomy of ejaculation and provide a review of the involvement of serotonin in the central nervous system in relation to serotonergic nuclei and their projections. A. hypothesis of the role of 5-HT1A and 5-HT2C receptors in premature ejaculation is postulated. (C) 1998 Elsevier Science B.V. All rights reserved.