AN EFFICIENT SYNTHESIS OF 3-CYANOQUINOLINE DERIVATIVES

Authors
CHARPENTIER P LOBREGAT V LEVACHER V DUPAS G QUEGUINER G BOURGUIGNON J
Citation
P. Charpentier et al., AN EFFICIENT SYNTHESIS OF 3-CYANOQUINOLINE DERIVATIVES, Tetrahedron letters, 39(23), 1998, pp. 4013-4016
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
23
Year of publication
1998
Pages
4013 - 4016
Database
ISI
SICI code
0040-4039(1998)39:23<4013:AESO3D>2.0.ZU;2-N
Abstract
A short aid efficient method is reported for the preparation of 3-cyan oquinoline derivatives. Reaction of 3,3-dimethoxy-2-formyl-propanenitr ile sodium salt 1 with various anilines 2 afforded (E) enamines 3 whic h were subsequently isomerized into (Z) enamines 4 and cyclized in a o ne pot procedure to give 3-cyanoquinolines 5 in good yields. (C) 1998 Elsevier Science Ltd. All rights reserved.