A NOVEL SYNTHESIS OF BETA-TRIFLUOROMETHYL-SUBSTITUTED ISOSERINE VIA INTRAMOLECULAR REARRANGEMENT OF IMINO ETHERS

Authors
UNEYAMA K HAO JA AMII H
Citation
K. Uneyama et al., A NOVEL SYNTHESIS OF BETA-TRIFLUOROMETHYL-SUBSTITUTED ISOSERINE VIA INTRAMOLECULAR REARRANGEMENT OF IMINO ETHERS, Tetrahedron letters, 39(23), 1998, pp. 4079-4082
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
23
Year of publication
1998
Pages
4079 - 4082
Database
ISI
SICI code
0040-4039(1998)39:23<4079:ANSOBI>2.0.ZU;2-N
Abstract
The methodology for the construction of beta-trifluoromethyl-substitut ed isoserine is reported The fluorinated alpha-hydroxy-beta-imino este rs which are the precursors to amino add derived isoserine were formed firstly via a base catalyzed intramolecular rearrangement of imino et hers, and the subsequent conversions of these compounds resulted in th e formation of the designed isoserines and the related fluorinated com pounds. (C) 1998 Elsevier Science Ltd. All rights reserved.