MECHANISM OF OXYGENATION OF NAPHTHOQUINONE DERIVATIVE

Authors
HAM SW LEE GH
Citation
Sw. Ham et Gh. Lee, MECHANISM OF OXYGENATION OF NAPHTHOQUINONE DERIVATIVE, Tetrahedron letters, 39(23), 1998, pp. 4087-4090
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
23
Year of publication
1998
Pages
4087 - 4090
Database
ISI
SICI code
0040-4039(1998)39:23<4087:MOOOND>2.0.ZU;2-E
Abstract
Vitamin K in its hydroquinone form, vitamin KH2, is transformed to vit amin K oxide concurrent with the abstraction of the gamma-hydrogen of Glu leading to Gla. The nonenzymatic model supports that oxygenation o f the monoanion of vitamin KH2 can produce the peroxy anion at the 4-p osition yielding vitamin K oxide. (C) 1998 Elsevier Science Ltd. All r ights reserved.