ASYMMETRIC AMINOHYDROXYLATION OF SUBSTITUTED STYRENES USING T-BUTYL CARBAMATE

A variety of substituted styrenes have been aminohydroxylated using t- butyl carbamate to give either enantiomer of highly enantiomerically e nriched N-Boc protected amino alcohols in good yields. Better levels o f regioselectivity were observed with (DHQ)(2)PHAL than with (DHQD)(2) PHAL even though the enantioselectivities observed were comparable. On e of the amino alcohol products was converted into a novel chiral diam ine. (C) 1998 Elsevier Science Ltd. All rights reserved.