A. Breitenbach et T. Kissel, BIODEGRADABLE COMB POLYESTERS - PART-1 - SYNTHESIS, CHARACTERIZATION AND STRUCTURAL-ANALYSIS OF POLY(LACTIDE) AND POLY(LACTIDE-CO-GLYCOLIDE) GRAFTED ONTO WATER-SOLUBLE POLY(VINYL ALCOHOL) AS BACKBONE, Polymer, 39(14), 1998, pp. 3261-3271
To overcome discontinuous or polyphasic drug release rates of parenter
al delivery systems (PDSs) for peptides and proteins, typical for line
ar polyesters, novel biodegradable brush-like poly(lactide) and poly(l
actide-co-glycolide) (PLG) grafted onto water-soluble poly(vinyl alcoh
ol) (PVA) as backbone were investigated. These polymers were synthesiz
ed by ring-opening melt polymerization using stannous octoate as catal
yst. The branched PVA-PLGs were characterized by 1D- and 2D-n.m.r. spe
ctroscopy and other methods, such as i.r., g.p.c., d.s.c. and static l
ight scattering. The incorporation of the backbone and the comb struct
ure was demonstrated by H-1- and C-13-n.m.r. spectra, as well as by li
ght scattering studies. The physico-chemical properties, such as molec
ular composition and architecture, molecular weight, degree of crystal
linity, melting point and glass transition point, could be systematica
lly adjusted to the requirements of drug delivery. Therefore, this new
class of biodegradable polymers has considerable potential as a PDS.
(C) 1998 Elsevier Science Ltd. All rights reserved.