APPLICATION OF THE SOLID DISPERSION METHOD TO THE CONTROLLED-RELEASE OF MEDICINE - PART X - CONTROL OF MEDICINE RELEASE FROM SOLID DISPERSION THROUGH POLY(ETHYLENE OXIDE) CARBOXYVINYLPOLYMER INTERACTION

Poly(ethylene oxide) (PEO)-carboxyvinylpolymer (CP) solid dispersions containing phenacetin (PHE) were prepared using water/ethanol mixture as a solvent. The solvent composition and the release behavior of PHE from the solid dispersions were studied. It was found that the mixture of water/ethanol (1/1, v/v) was useful for the solvent to prepare sol id dispersions. The release rate of PHE from the PHE-PEO system was la rger than that from PHE powder. In the PHE-CP system, almost the same release rate was observed as PHE powder. The release rate from the PHE -PEO-CP system obviously varied depending on the PEO/CP ratio and reac hed the minimum level at the PEO/CP ratio of 1/1 (w/w). FT-IR spectra suggested the interaction of hydrogen bonding between PEO and CP. Thes e results indicate that it is feasible to control the medicine release from the solid dispersions by using PEO and CP. (C) 1998 Elsevier Sci ence B.V. All rights reserved.