PARALLEL SYNTHESIS OF 3-AMINOIMIDAZO[1,2-A]PYRIDINES AND PYRAZINES BYA NEW 3-COMPONENT CONDENSATION

Authors
BLACKBURN C GUAN B FLEMING P SHIOSAKI K TSAI S
Citation
C. Blackburn et al., PARALLEL SYNTHESIS OF 3-AMINOIMIDAZO[1,2-A]PYRIDINES AND PYRAZINES BYA NEW 3-COMPONENT CONDENSATION, Tetrahedron letters, 39(22), 1998, pp. 3635-3638
Citations number
32
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
22
Year of publication
1998
Pages
3635 - 3638
Database
ISI
SICI code
0040-4039(1998)39:22<3635:PSO3AP>2.0.ZU;2-J
Abstract
A three-component condensation reaction between 2-aminopyridine, an al dehyde and an isonitrile catalyzed by scandium triflate affords deriva tives of 3-aminoimidazo[1,2-a]pyridine; aminopyrazine reacts similarly . A library of heterocycles, prepared in high yield by parallel synthe sis and purification on an ion-exchange resin, was subjected to furthe r reactions at the amino group. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.