AN EFFICIENT SYNTHESIS OF ALPHA-ACYLOXYKETONE BY CU(ACAC)(2)-CATALYZED INSERTION REACTION OF ALPHA-DIAZOKETONE TO CARBOXYLIC-ACID

Authors
SHINADA T KAWAKAMI T SAKAI H TAKADA I OHFUNE Y
Citation
T. Shinada et al., AN EFFICIENT SYNTHESIS OF ALPHA-ACYLOXYKETONE BY CU(ACAC)(2)-CATALYZED INSERTION REACTION OF ALPHA-DIAZOKETONE TO CARBOXYLIC-ACID, Tetrahedron letters, 39(22), 1998, pp. 3757-3760
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
22
Year of publication
1998
Pages
3757 - 3760
Database
ISI
SICI code
0040-4039(1998)39:22<3757:AESOAB>2.0.ZU;2-5
Abstract
An efficient insertion reaction of alpha-diazoketone to various carbox ylic acids was achieved by using Cu(acac)(2) as a catalyst. Treatment of the diazo compound with a carboxylic acid (1.2 equiv) in the presen ce of Cu(acac)(2) (0.1 equiv) at room temperature afforded the corresp onding ketoester in good yield. Various kinds of functional groups wer e tolerated under the reaction conditions. (C) 1998 Elsevier Science L td. All rights reserved.