HIGH-AVIDITY AUTOANTIBODIES TO CYTOKINES

The increased use of recombinant cytokines and cytokine analogues in v arious disease therapies emphasizes the importance of antibodies to cy tokines. Here, Klaus Bendtzen and colleagues discuss how immunological tolerance to cytokines may be broken, and the clinical relevance of c ytokine autoantibodies. They also comment on the implications for refi ned passive immunization and cytokine vaccination strategies.