PREPARATION, CHARACTERIZATION, AND DISSOLUTION STUDIES OF IBUPROFEN SOLID DISPERSIONS USING POLYETHYLENE-GLYCOL (PEG), TALC, AND PEG-TALC AS DISPERSION CARRIERS

Solid dispersions of ibuprofen (IBF) were prepared by solvent evaporat ion method using polyethylene glycol 10000 (PEG), talc, and PEG-talc a s dispersion carriers. The drug-carrier(s) interactions in the solid s tate were investigated using scanning electron microscopy (SEM), diffe rential scanning calorimetry (DSC), and x-ray diffraction analysis. In teractions in the solution were studied by performing dissolution expe riments. No important and well-defined chemical interaction was found between the ingredients. The increase in the IBF dissolution rate from the solid dispersions with the carriers used in this study could be a ttributed to several factors such as improved wettability, local solub ilization, and drug particle size reduction.