PREPARATION, CHARACTERIZATION, AND EVALUATION OF PHYSICOCHEMICAL PROPERTIES OF DIFFERENT CRYSTALLINE FORMS OF IBUPROFEN

Different crystal forms of ibuprofen (IBF) were prepared using methods such as cooling hot solution of the drug and precipitation of crystal s from the drug solution. Scanning electron microscopy (SEM), differen tial scanning calorimetry (DSC), melting point, x-ray powder diffracto metry, infrared absorption spectroscopy (IR), and in vitro dissolution rate and stability studies were conducted to investigate various char acteristics of different crystalline forms of the drug. Methods of pre paration and nature of the solvents used in this study were found to h ave greater roles in changing the physicochemical properties of IBF.