NEW ACETYLENE BASED HISTAMINE H-2-RECEPTOR ANTAGONISTS DERIVED FROM THE MARINE NATURAL PRODUCT VERONGAMINE

Authors
ALI SM TEDFORD CE GREGORY R YATES SL PHILLIPS JG
Citation
Sm. Ali et al., NEW ACETYLENE BASED HISTAMINE H-2-RECEPTOR ANTAGONISTS DERIVED FROM THE MARINE NATURAL PRODUCT VERONGAMINE, Bioorganic & medicinal chemistry letters, 8(10), 1998, pp. 1133-1138
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
10
Year of publication
1998
Pages
1133 - 1138
Database
ISI
SICI code
0960-894X(1998)8:10<1133:NABHHA>2.0.ZU;2-#
Abstract
New histamine H-3 receptor antagonists were developed using an acetyle ne moiety as a replacement or the amide-oxime functionality of veronga mine 5. Optimization of receptor binding was performed by following al iphatic Topliss tree guidelines. These new H-3 ligands demonstrate exc ellent blood-brain barrier penetration. (C) 1998 Elsevier Science Ltd. All rights reserved.