RECOGNITION OF A NONSTANDARD BASE-PAIR BY THERMOSTABLE DNA-POLYMERASES

Authors
LUTZ MJ HORLACHER J BENNER SA
Citation
Mj. Lutz et al., RECOGNITION OF A NONSTANDARD BASE-PAIR BY THERMOSTABLE DNA-POLYMERASES, Bioorganic & medicinal chemistry letters, 8(10), 1998, pp. 1149-1152
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
10
Year of publication
1998
Pages
1149 - 1152
Database
ISI
SICI code
0960-894X(1998)8:10<1149:ROANBB>2.0.ZU;2-4
Abstract
Examination of several commercially available thermostable DNA polymer ases identifies 9 degrees N DNA polymerase as single enzyme that could incorporate two components of an expanded genetic alphabet, 2,4-diami nopyrimidine and xanthosine as deoxynucleoside triphosphate opposite t heir cognate base in a DNA template. (C) 1998 Elsevier Science Ltd. Al l rights reserved.