MALONYL ALPHA-MERCAPTOKETONES AND ALPHA-MERCAPTOALCOHOLS, A NEW CLASSOF MATRIX METALLOPROTEINASE INHIBITORS

Authors
CAMPBELL DA XIAO XY HARRIS D IDA S MORTEZAEI R NGU K SHI LH TIEN D WANG YW NAVRE M PATEL DV SHARR MA DIJOSEPH JF KILLAR LM LEONE CL LEVIN JI SKOTNICKI JS
Citation
Da. Campbell et al., MALONYL ALPHA-MERCAPTOKETONES AND ALPHA-MERCAPTOALCOHOLS, A NEW CLASSOF MATRIX METALLOPROTEINASE INHIBITORS, Bioorganic & medicinal chemistry letters, 8(10), 1998, pp. 1157-1162
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
10
Year of publication
1998
Pages
1157 - 1162
Database
ISI
SICI code
0960-894X(1998)8:10<1157:MAAAAN>2.0.ZU;2-H
Abstract
A novel series of matrix metalloproteinase (MMP) inhibitors is describ ed. Incorporation of a terminal alpha-mercaptoketone or alpha-mercapto alcohol in the zinc binding domain of a series of inhibitors led to co mpounds exhibiting low nanomolar activity against collagenase-1 (MMP-1 ), stromelysin (MMP-3), and gelatinase-B (MMP-9). (C) 1998 Elsevier Sc ience Ltd. All rights reserved.