THE ASYMMETRIC-SYNTHESIS AND IN-VITRO CHARACTERIZATION OF SUCCINYL MERCAPTOALCOHOL AND MERCAPTOKETONE INHIBITORS OF MATRIX METALLOPROTEINASES

Authors
LEVIN JI DIJOSEPH JF KILLAR LM SHARR MA SKOTNICKI JS PATEL DV XIAO XY SHI LH NAVRE M CAMPBELL DA
Citation
Ji. Levin et al., THE ASYMMETRIC-SYNTHESIS AND IN-VITRO CHARACTERIZATION OF SUCCINYL MERCAPTOALCOHOL AND MERCAPTOKETONE INHIBITORS OF MATRIX METALLOPROTEINASES, Bioorganic & medicinal chemistry letters, 8(10), 1998, pp. 1163-1168
Citations number
42
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
10
Year of publication
1998
Pages
1163 - 1168
Database
ISI
SICI code
0960-894X(1998)8:10<1163:TAAICO>2.0.ZU;2-J
Abstract
A series of succinyl based mercaptoketones and diastereomeric mercapto alcohols were prepared and evaluated in vitro as inhibitors of the mat rix metalloproteinases collagenase-1 (MMP-1), stromelysin (MMP-3), and gelatinase-B (MMP-9). (C) 1998 Elsevier Science Ltd. All rights reser ved.