ANTIINFLAMMATORY 2-BENZYL-4-SULFONYL-4H-ISIOQUINOLINE-1,3-DIONES - NOVEL INHIBITORS OF COX-2

Authors
LAZER ES SORCEK R CYWIN CL THOME D POSSANZA GJ GRAHAM AG CHURCHILL L
Citation
Es. Lazer et al., ANTIINFLAMMATORY 2-BENZYL-4-SULFONYL-4H-ISIOQUINOLINE-1,3-DIONES - NOVEL INHIBITORS OF COX-2, Bioorganic & medicinal chemistry letters, 8(10), 1998, pp. 1181-1186
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
10
Year of publication
1998
Pages
1181 - 1186
Database
ISI
SICI code
0960-894X(1998)8:10<1181:A2-N>2.0.ZU;2-R
Abstract
A series of 2-benzyl-4-sulfonyl-4H-isoquinoline-1,3-diones was prepare d. Members of this series are potent and selective inhibitors of cyclo oxygenase-2 (COX-2) in both microsomal and cellular assays. Two repres entatives demonstrated activity in the carrageenan-induced paw edema m odel in rats upon oral administration. (C) 1998 Elsevier Science Ltd. All rights reserved.