IN-VITRO EVALUATION OF SYNTHETIC HEPARIN-LIKE CONJUGATES COMPRISING DIFFERENT THROMBIN BINDING DOMAINS

Authors
BASTEN JEM DREEFTROMP CM DEWIJS B VANBOECKEL CAA
Citation
Jem. Basten et al., IN-VITRO EVALUATION OF SYNTHETIC HEPARIN-LIKE CONJUGATES COMPRISING DIFFERENT THROMBIN BINDING DOMAINS, Bioorganic & medicinal chemistry letters, 8(10), 1998, pp. 1201-1206
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
10
Year of publication
1998
Pages
1201 - 1206
Database
ISI
SICI code
0960-894X(1998)8:10<1201:IEOSHC>2.0.ZU;2-O
Abstract
The syntheses of several heparin-like glycoconjugates (i.e., 16a-f) co ntaining identical AT III binding domains (ABD) and spacers but differ ent thrombin binding domains (TBDs) are described.(1) Biological activ ities of conjugates 16a-f indicate that the thrombin inhibitory activi ty is mainly determined by the charge density of the TBD moiety. (C) 1 998 Elsevier Science Ltd. All rights reserved.