DESIGN AND SYNTHESIS OF BIO-ISOSTERES OF THYMIDINE TRIPHOSPHATE

Authors
GOLDRING AO BALZARINI J GILBERT IH
Citation
Ao. Goldring et al., DESIGN AND SYNTHESIS OF BIO-ISOSTERES OF THYMIDINE TRIPHOSPHATE, Bioorganic & medicinal chemistry letters, 8(10), 1998, pp. 1211-1214
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
10
Year of publication
1998
Pages
1211 - 1214
Database
ISI
SICI code
0960-894X(1998)8:10<1211:DASOBO>2.0.ZU;2-G
Abstract
This paper describes the design and synthesis of potential isosteres o f triphosphates which should show enhanced metabolic stability and lip ophilicity compared to triphosphates. The triphosphate isosteres were then linked to nucleosides and evaluated for their inhibitory activity against HIV infection. (C) 1998 Elsevier Science Ltd. All rights rese rved.