UV SPECTROSCOPY STUDY ON COMPLEXES OF PHOSPHONATE APA ANALOGS WITH POLY(U) - PROMISING STEP IN PREDICTION OF OLIGONUCLEOTIDE ANALOG PROPERTIES

Authors
PRESSOVA M ENDOVA M TOCIK Z LIBOSKA R ROSENBERG I
Citation
M. Pressova et al., UV SPECTROSCOPY STUDY ON COMPLEXES OF PHOSPHONATE APA ANALOGS WITH POLY(U) - PROMISING STEP IN PREDICTION OF OLIGONUCLEOTIDE ANALOG PROPERTIES, Bioorganic & medicinal chemistry letters, 8(10), 1998, pp. 1225-1230
Citations number
24
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
10
Year of publication
1998
Pages
1225 - 1230
Database
ISI
SICI code
0960-894X(1998)8:10<1225:USSOCO>2.0.ZU;2-B
Abstract
The isopolar nonisosteric phosphonate analogs of ApA differing in the position of extra methylene group introduced into the sugar-phosphate backbone, featuring both possible 2',5'- and 3',5'- pairs as well as t heir conformationally restricted congeners, were investigated for thei r ability to form complexes with polyU. The results may lead to the sp ecification of candidates for synthesis of novel oligonucleotides. (C) 1998 Elsevier Science Ltd. All rights reserved.