SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF [6,5,5] AND [6,6,5] TRICYCLICFUSED OXAZOLIDINONES

Authors
GLEAVE DM BRICKNER SJ MANNINEN PR ALLWINE DA LOVASZ KD ROHRER DC TUCKER JA ZURENKO GE FORD CW
Citation
Dm. Gleave et al., SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF [6,5,5] AND [6,6,5] TRICYCLICFUSED OXAZOLIDINONES, Bioorganic & medicinal chemistry letters, 8(10), 1998, pp. 1231-1236
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
10
Year of publication
1998
Pages
1231 - 1236
Database
ISI
SICI code
0960-894X(1998)8:10<1231:SAAAO[>2.0.ZU;2-3
Abstract
A series of conformationally restricted, [6,5,5] and [6,6,5] tricyclic fused oxazolidinones were synthesized and tested for antibacterial ac tivity. Several compounds in the trans-[6,5,5] series demonstrated pot ent in vitro and in vivo activity. This work provides valuable informa tion regarding the preferred conformational orientation of the oxazoli dinones site. (C) 1998 Elsevier Science Ltd. All rights reserved.