NONPEPTIDIC HIV PROTEASE INHIBITORS - C-2-SYMMETRY-BASED DESIGN OF BIS-SULFONAMIDE DIHYDROPYRONES

Authors
JANAKIRAMAN MN WATENPAUGH KD TOMICH PK CHONG KT TURNER SR TOMMASI RA THAISRIVONGS S STROHBACH JW
Citation
Mn. Janakiraman et al., NONPEPTIDIC HIV PROTEASE INHIBITORS - C-2-SYMMETRY-BASED DESIGN OF BIS-SULFONAMIDE DIHYDROPYRONES, Bioorganic & medicinal chemistry letters, 8(10), 1998, pp. 1237-1242
Citations number
7
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
10
Year of publication
1998
Pages
1237 - 1242
Database
ISI
SICI code
0960-894X(1998)8:10<1237:NHPI-C>2.0.ZU;2-5
Abstract
Potent, non-peptidic, dihydropyrone sulfonamide HIV protease inhibitor s have been previously described. Crystallographic analysis of dihydro pyrone sulfonamide inhibitor/HIV protease complexes suggested incorpor ation of a second, C-2 symmetry-related sulfonamide group. Selected bi s-sulfonamide dihydropyrone analogues display high HIV protease inhibi tory activity. (C) 1998 Elsevier Science Ltd. All rights reserved.