3-TRIFLUOROMETHYLCARBACEPHEMS - SYNTHESIS OF BROAD-SPECTRUM ANTIBACTERIAL COMPOUNDS

Authors
COOK GK HORNBACK WJ MCDONALD JH MUNROE JE SNYDER NJ
Citation
Gk. Cook et al., 3-TRIFLUOROMETHYLCARBACEPHEMS - SYNTHESIS OF BROAD-SPECTRUM ANTIBACTERIAL COMPOUNDS, Bioorganic & medicinal chemistry letters, 8(10), 1998, pp. 1261-1266
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
10
Year of publication
1998
Pages
1261 - 1266
Database
ISI
SICI code
0960-894X(1998)8:10<1261:3-SOBA>2.0.ZU;2-C
Abstract
The enhanced stability of the carbacephem nucleus over the correspondi ng cephalosporin nucleus has allowed the synthesis of 7-arylglycyl-3-t rifluoromethyl-carbacephems. These unique carbacephems possess broad s pectrum activity and high stability to both plasmid and chromosomally mediated beta-lactamases. (C) 1998 Elsevier Science Ltd. All rights re served.