TETRACYCLIC TRITERPENOIDS OF THE FRUIT COATS OF AZADIRACHTA-INDICA

From the ethanolic extract of the fresh fruit coats of Azadirachta ind ica (neem), four new tetracyclic triterpenoids salimuzzalin [24,25,26, 27-tetranorapotirucalla(apoeupaa)-7 alpha-hydroxy-21 xi,23 xi-diacetox y-21,23-epoxy-1,14,20(22)-trien-3-one], azadirolic acid [26,27-dinorap otirucalla(apoeupha)-6 beta-acetoxy-7 alpha-hydroxy- 1,14,20(22)-trien -3-one-25-oic acid], azadiradionol [26,27-dinorapotirucalla(apoeupha)- 7 alpha-acetoxy-24 xi-hydroxy- 1,14-dien-3,16-dione] and azadironol [4 ,4,8-trimethyl-5 alpha-(13 alpha Me)-androst-17 alpha-hydroxy-1-en-7 a lpha(p-methoxy, m-hydroxy trans cinnamoyloxy)-3-one], were isolated. T heir structures were elucidated through spectroscopic techniques. (C) 1998 Elsevier Science Ltd. All rights reserved.