INTRAGENIC RECOMBINATIONS IN ROTAVIRUSES

Authors
SUZUKI Y GOJOBORI T NAKAGOMI O
Citation
Y. Suzuki et al., INTRAGENIC RECOMBINATIONS IN ROTAVIRUSES, FEBS letters, 427(2), 1998, pp. 183-187
Citations number
23
Categorie Soggetti
Biology,"Cell Biology",Biophysics
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
427
Issue
2
Year of publication
1998
Pages
183 - 187
Database
ISI
SICI code
0014-5793(1998)427:2<183:IRIR>2.0.ZU;2-K
Abstract
In this paper, evidence for intragenic recombination in the VP7 gene b etween rotavirus strains bearing different serotypes is demonstrated f or the first time. Intragenic recombination may be one of the escaping mechanisms from the host immune system for rotavirus. This process in volves exchanging antigenic regions, thus questioning the use of multi valent vaccines for the prevention of rotavirus infection. (C) 1998 Fe deration of European Biochemical Societies.