(S)-3,7-DIMETHYL-5-OCTENE-1,7-DIOL AND RELATED OXYGENATED MONOTERPENOIDS FROM PETALS OF ROSA-DAMASCENA MILL

The methanolic extract obtained from rose flowers was subjected to XAD -8 adsorption chromatography. Prefractionation of the methanolic eluat e using multilayer coil countercurrent chromatography (MLCCC) yielded five subfractions. From the least polar subfraction V, a major amount of the key odorants of rose oil, that is, isomeric rose oxides 1a/b, w as liberated upon heat treatment at pH 2.5. Further chromatographic wo rkup of fraction V led, for the first time, to the identification of t he genuine rose oxide precursor (S)-3,7-dimethyl-5-octene-1,7-diol (2) . In addition to diol 2, the following monoterpene diols have been ide ntified: 3,7-dimethyl-7-octene-1,6-diol (3), 2,6-dimethyl-1,7-octadien e-3,6-diol (4), (2E,5E)-3,7-dimethyl-2,5-octadiene-1,7-diol (5), (2E)- 3,7-dimethyl-2,7octadiene-1,6-diol (6), (2Z,5E)-3,7-dimethyl-2,5-octad iene-1,7-diol (7), (2Z)-3,7-dimethyl-2,7-octadiene-1,6-diol (8), (Z)-2 ,6-dimethyl-2-octene-1,8-diol (9), (E)-2,6-dimethyl-2-octene-1,8-diol( 10), (2)-2,6-dimethyl-2,7-octadiene-1 ,6-diol(ll), (E)-2,6-dimethyl-2, 7-octadiene-1,6-diol (12), (2E,GE)-2,6-dimethyl-2 ,6-octadiene-1,8-dio l(13), (2E,6Z)-2,6-dimethyl-2,6-octadiene-1,8-diol(14), 2,6-dimethyloc tane-1,8-diol(15), 2,6-dimethyl-7-octene-1,6-diol (16), (E)-3,7-dimeth yl-2-octene-1,8-diol (17), (Z)-3,7-dimethyl-2-octene-1,8-diol (18), 3, 7-dimethyloctane-1,7-diol (19), 2,6-dimethyl-7-octene-2,6-diol (20), 3 ,7-dimethyl-6-octene-1,3-diol (21) and (2E)-3,7-dimethyl-2,6-octadiene -1,4-diol (22).