SYNTHESIS OF A POTENT INHIBITOR OF HIV REVERSE-TRANSCRIPTASE

Authors
HAMILTON CJ ROBERTS SM SHIPITSIN A
Citation
Cj. Hamilton et al., SYNTHESIS OF A POTENT INHIBITOR OF HIV REVERSE-TRANSCRIPTASE, Chemical communications, (10), 1998, pp. 1087-1088
Citations number
13
Categorie Soggetti
Chemistry
Journal title
Chemical communications → ACNP
ISSN journal
13597345
Issue
10
Year of publication
1998
Pages
1087 - 1088
Database
ISI
SICI code
1359-7345(1998):10<1087:SOAPIO>2.0.ZU;2-G
Abstract
The newly synthesised P-beta,-P-gamma-difluoromethylenebisphosphonate analogue 2 of nor-carbovir triphosphate is a potent inhibitor of HIV r everse transcriptase; it also exhibits a greatly enhanced stability to dephosphorylation, in foetal blood serum, relative to AZTTP and other nucleoside triphosphates.