Mw. Cappi et al., NEW PROCEDURES FOR THE JULIA-COLONNA ASYMMETRIC EPOXIDATION - SYNTHESIS OF (-CLAUSENAMIDE()), Chemical communications, (10), 1998, pp. 1159-1160
The oxidation of chalcone 1 to optically active epoxide 2 [a precursor
of (+)-clausenamide (+)-3] may be effected using a 15-mer or 20-mer o
f L-leucine bound to a PEG based support; poly-L-leucines of this type
may be used as immobilised catalysts in a fixed-bed reactor.