PRIMARY CENTRAL-NERVOUS-SYSTEM LYMPHOMA IN A CHILD WITH ACUTE B-CELL LYMPHOBLASTIC-LEUKEMIA - CONSECUTIVE EPSTEIN-BARR VIRUS-RELATED MALIGNANCIES

Primary central nervous system lymphoma (PCNSL), observed among immuno compromised AIDS patients, has not been reported during chemotherapy f or acute lymphoblastic leukaemia (ALL), We report a case of PCNSL occu rring in a child receiving intensive multiagent chemotherapy for B-cel l ALL. In situ hybridization studies demonstrated Epstein-Barr virus g enome in both tumours, suggesting a possible link between the two dise ases. The clinical response of the PCNSL to conservative therapy highl ights the importance of accurately diagnosing such EBV-related disorde rs, especially in patients where immune compromise can be reversed.