Background. A cardinal feature of schizophrenia is the sufferer's diff
iculty in interacting appropriately within the social milieu. This def
icit has recently been associated with the concept of theory of mind,
more commonly construed as a working model to understand behavioural p
atterns in autistic children. In this paper the complex relationships
between theory of mind, IQ and psychoses are addressed. Methods. Five
experimental groups were used; non-psychiatric controls, affective dis
order, schizophrenia with normal pre-morbid IQ, schizophrenia with pre
-morbid IQ in the mildly learning disabled range, and mild learning di
sability with no history of psychiatric illness. All subjects were giv
en a first order Theory of Mind Task and if successful, a second order
Theory of Mind Task was then administered. All subjects were rated us
ing the Positive and Negative Symptom Scale (PANSS). Results. Subjects
with schizophrenia and subjects with mild learning disability show im
paired ability on a second order theory of mind task. However, when pa
tients who are unable to answer reality questions are removed from the
analysis specific impairment of theory of mind is only seen in subjec
ts with schizophrenia. Furthermore, this impairment is relatively spec
ific to particular psychopathological clusters in subjects with schizo
phrenia. Even though the same clusters of psychopathology are also see
n in patients with affective disorder, their presence is not associate
d with poor second order theory of mind performance. Conclusions. Impa
ired theory of mind on second order tests is specific to schizophrenia
when compared to mild learning disability and affective disorder cont
rol groups. Subjects with schizophrenia and pre-morbid mild learning d
isability show greater impairment than subjects with schizophrenia and
a pre-morbid IQ within the normal range.