POLYISOBUTYLCYANOACRYLATE NANOPARTICLES AS DRUG CARRIERS - INFLUENCE OF SULFUR-DIOXIDE ON THE PHYSICOCHEMICAL CHARACTERISTICS OF CIPROFLOXACIN-LOADED AND DOXORUBICIN-LOADED NANOPARTICLES

Authors
PAGECLISSON ME GIBAUD S PINTOALPHANDARY H WEINGARTEN C COUVREUR P
Citation
Me. Pageclisson et al., POLYISOBUTYLCYANOACRYLATE NANOPARTICLES AS DRUG CARRIERS - INFLUENCE OF SULFUR-DIOXIDE ON THE PHYSICOCHEMICAL CHARACTERISTICS OF CIPROFLOXACIN-LOADED AND DOXORUBICIN-LOADED NANOPARTICLES, International journal of pharmaceutics, 166(1), 1998, pp. 117-120
Citations number
9
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
International journal of pharmaceutics → ACNP
ISSN journal
03785173
Volume
166
Issue
1
Year of publication
1998
Pages
117 - 120
Database
ISI
SICI code
0378-5173(1998)166:1<117:PNADC->2.0.ZU;2-Y
Abstract
The amount of sulfur dioxide present in isobutylcyanoacrylate monomer was examined for the entrapment of ciprofloxacin and doxorubicin into poly(isobutylcyanoacrylate) nanoparticles obtained by emulsion polymer ization. In fact, SO2, commonly used as a polymerization inhibitor, wa s shown to be a crucial factor modulating the polymerization process. In this report, its optimal concentration to have reproducible prepara tions regarding size and highest association extent was about 0.5% for both drugs. (C) 1998 Elsevier Science B.V. All rights reserved.